Take Relivaid when the cramps hit.
Naturally derived cramp relief formulated by doctors for fast, effective relief that isn’t harsh on your body.
4.8(51)30-day money-back guarantee
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Cramp relief that works fast.
Naturally derived actives are usually the ones that struggle to be absorbed, so each of ours is paired with a delivery system built around how that particular molecule moves, for rapid absorption.
more soluble than standard PEA, the active that quiets the nerve signaling behind cramp pain
Measured in simulated intestinal fluid. Khan et al, Biomedicines 2026.
improvement in gingerol solubility, the active that lowers prostaglandins driving your cramps
Water solubility index against ginger oleoresin. Amalraj et al, ACS Food Science and Technology 2021.
typical time to cramp relief
Reported by Relivaid customers. Most within 60 minutes, the majority in as little as 30. Not a clinical trial result.
Say goodbye to cramps in a format you feel good about taking.
Relivaid lets you ditch the solutions that can cause stomach damage or make you feel like you can only take it when the cramps get really bad.
Relivaid also works on the lower back ache that comes with your cramps.
Relivaid also eases the PMS headaches with caffeine acting as a vasoconstrictor.
Relivaid also helps with the heavy, wiped-out feeling that arrives with cramps and your period.
Here’s what our customers have to say
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Relivaid™Fast-Acting Cramp Relief
(51)Naturally derived cramp support with a pharmaceutical-grade delivery system on every active, formulated by doctors and gentle enough on your stomach to take the moment cramps start.
- Menstrual cramps
- PMS headaches
- Lower back ache
- Joint and muscle aches
How would you like to buy?
1 Bottle
2 Bottles
3 Bottles
- 30-day money-back guarantee
- Formulated by doctors
- Naturally derived bioactives
- Rapid absorption
How to best use Relivaid for cramp relief
Relivaid works on a single dose and it is safe to keep taking through the day, so you can use it as needed rather than every day of your cycle.
Take two capsules the moment cramps start
With Relivaid, you can take it as needed. We designed this not as a daily supplement but rather something you keep in the medicine cabinet.
Start a day early if you know they are coming
Starting Relivaid the day before your cramps hit helps to reduce the prostaglandin buildup in the uterus that drives the next day aches.
Repeat up to three times through the day
Relivaid is safe to take up to three times a day, spaced a few hours apart, so you can keep going for as long as the cramps do.
Dr. Kennard, DO, OB-GYN
Triple-board certified, Trelli Medical Advisor
If you are pregnant, breastfeeding or taking other medication, speak to your healthcare provider first.
Three actives, all built for rapid absorption.
We select only clinically studied actives for menstrual cramp relief, focusing on forms that have improved bioavailability so you get the cramp relief you need and fast.
Bio-Optimized Gingerols
Polar and non-polar sandwiching
Gingerols reduce prostaglandin production in the uterus, so there is less for the muscle to contract against. Ours sit between polar and non-polar layers, so the package travels through the watery gut and across fatty cell membranes instead of passing through you.
Phospholipid-Bound PEA
Phospholipid complex
PEA is a compound your body already makes, and it calms the nerve signalling that keeps cramps loud once they have started. Binding it into a phospholipid complex, the same class of molecule your cell membranes are built from, markedly improves how much of it dissolves and becomes available.
USP-Grade Caffeine
No delivery system needed
Small and water soluble enough to absorb within minutes on its own. At 50 mg for a two capsule dose, roughly half a cup of coffee, it is there to help the other two actives land rather than to pick you up.
With Relivaid, we check every box.
Relivaid is supported by Trelli’s Medical Advisory Board made up of physicians, scientists and leading experts, and more than 675 clinicians now share Relivaid with their patients without compensation. Meet the people behind our formulas.
Dr. Anne Kennard
DO, OBGYN, FACLM, Dipl-ABOIM
Board-certified OB-GYN and integrative medicine physician with deep expertise in women's hormonal health and lifestyle medicine.
Board-certified OB-GYN and integrative medicine physician with deep expertise in women's hormonal health and lifestyle medicine.
Dr. Stephen Dahmer
MD
Medical Director at the Andrew Weil Center for Integrative Medicine. Pioneering the clinical integration of conventional and natural therapies.
Medical Director at the Andrew Weil Center for Integrative Medicine. Pioneering the clinical integration of conventional and natural therapies.
Dr. Jacqueline Jacques
ND
Former Chief Research Officer at Thorne with 15+ years of leading evidence-based formulation at the health and wellness industry's highest standard.
Former Chief Research Officer at Thorne with 15+ years of leading evidence-based formulation at the health and wellness industry's highest standard.
Dr. Lisa Offringa
PhD, Medical and Nutritional Ethnobotany
Expert in the science of botanical ingredients, bridging traditional plant medicine with modern clinical evidence and precision formulation.
Expert in the science of botanical ingredients, bridging traditional plant medicine with modern clinical evidence and precision formulation.
Dr. Margo Bachman
DACM, L.Ac., CFMP
Doctor of Acupuncture and Chinese Medicine specializing in women's hormonal health, herbal formulation, and functional medicine approaches.
Doctor of Acupuncture and Chinese Medicine specializing in women's hormonal health, herbal formulation, and functional medicine approaches.
Dr. Robert Bonakdar
MD, FACN, ABOIM, FAAFP
Director of Pain Management at Scripps Center for Integrative Medicine and is a nationally recognized leader in evidence based integrative pain care.
Director of Pain Management at Scripps Center for Integrative Medicine and is a nationally recognized leader in evidence based integrative pain care.
Dr. Stacey Bell
DSc, Nutrition
Former faculty at Harvard Medical School with decades of expertise in clinical nutrition science and evidence-based nutritional product development.
Former faculty at Harvard Medical School with decades of expertise in clinical nutrition science and evidence-based nutritional product development.
Dr. Igor Koturbash
MD, PhD, Biomolecular Sciences
Leading researcher in ingredient safety and toxicology, ensuring every compound meets rigorous clinical standards before inclusion in any formulation.
Leading researcher in ingredient safety and toxicology, ensuring every compound meets rigorous clinical standards before inclusion in any formulation.
Dr. Tina Kaczor
ND, FABNO
Former Editor-in-Chief of the Natural Medicine Journal, a leading voice in evidence-based integrative, and clinical research across naturopathic oncology.
Former Editor-in-Chief of the Natural Medicine Journal, a leading voice in evidence-based integrative, and clinical research across naturopathic oncology.
What does rapid absorption actually mean here?
Each active is paired with a delivery system that helps it dissolve and cross into the bloodstream rather than passing through. The PEA is bound into a phospholipid complex, the gingerols sit between polar and non-polar layers so the package moves through both the watery gut and fatty cell membranes, and the small amount of caffeine is water soluble enough to need no help at all. Dose on a label only matters if your body can take it up.
When in my cycle should I take it?
Most women take it at the first cramp, and a single dose is enough for it to work, so you do not have to plan around it. If you know your cramps are coming, starting a day or two before your period helps reduce them further, because the gingerols lower prostaglandin production in the uterus and there is less of the signal that drives the cramping to begin with.
How fast will I feel it?
Average time to relief is 30 minutes, based on real customer data. Most people notice something within 30 to 60 minutes depending on the day and how early they take it.
Do I have to take it every day?
No, and that is the point. Relivaid is made for the moment cramps hit rather than as a daily routine you have to keep up all month. It is also safe to take daily if you have ongoing pain or you are managing inflammation, so you have both options.
Is it really naturally derived?
The three actives are naturally derived, and the delivery systems around them are what make them work at this speed. The caffeine is pharmaceutical grade rather than extracted, at 50 mg for a two capsule dose, which is roughly half a cup of coffee and is there to help the other two actives land rather than to pick you up.
Can I take this instead of what I usually take for cramps?
Many customers use Relivaid in place of what they usually reach for, and it is formulated to match that level of relief rather than exceed it. If your cramps are severe enough that nothing over the counter has helped, talk to your doctor. We would rather tell you that than sell you something that disappoints.
What is not in it?
No drug actives, no dyes, no major allergens and no gluten, and it is vegan. It is third-party tested, and it is formulated to be gentle on your liver and your stomach, which is the usual trade you make with conventional options.
Can I take it with other supplements or medications?
In general, Trelli products are safe to use alongside most supplements and medications. However, because everyone’s health profile is unique, we recommend speaking with your healthcare provider before combining any products.
Can I take it if I am pregnant or breastfeeding?
If you are pregnant or breastfeeding, please consult your healthcare professional before use. While our ingredients are naturally derived and well-tolerated, your provider can best guide what is appropriate for your individual needs.
