Let's Talk A Note from the Founder

  • I founded Trelli more than a year ago. 
But, the idea for Trelli isn’t new. Cleaner, better-for-you relief in the form of natural ingredients; that’s been around for ages. Centuries even.

    But, at Trelli, we know that science has progressed dramatically and we want to incorporate those advancements into the products we create to give you the best form of relief, that you can trust.

    Naturally derived ingredients means we start with nature and we standardize, optimize and combine those natural bioactives with delivery technologies to create a solution that is clinically sound, safe and efficacious.

    That clinical backing is crucial to Trelli and our products. I founded Trelli to be a science first company. Our claims are not promises for an improved metabolism, enhanced cognition, perfected skin - rather - we focus on your symptoms, 
and taking those away.

  • Think of a Trelli product as a cause and effect relationship. When you have abdominal cramping and nausea, take Colomend. When you have menstrual pain take Relivaid. When you have respiratory concerns take Respifix. 
When you feel better, put us back in 
the medicine cabinet.

    Because, we are not your average supplement. I hope you never have to take our products on the daily. I hope you think of us only as a resource for helping to feel better from whatever discomfort you have in that moment. We want to be taken on the bad days. The hard days. The days when you just need some relief. Forget about us on the good days. It’s why we don’t do subscriptions - there’s enough of that in the world already.

    And to be that partner on the hardest days, means we need to earn your trust. For that, we try to be upfront in our science, our clinical end points. Ongoing clinical work.

  • I started Trelli because of my own personal health crisis with conventional OTC medicine. My IBS reacted so poorly to many OTC medications from gastric irritation to abdominal cramping. I wanted something else I could trust and rely on.

    Trelli became that solution and working with our medical advisory board and partners, we spent over a year developing the solutions we have today.

    We can’t wait to show the world what natural relief can look like. Because it’s more than just feeling better. It’s about feeling good about how we get there.

High Standards
for Real Results.

Formulated by Trusted Experts

Validated by Clinicals & Continued Investment.

Trust Ingredients with Established Safety.

Results in a Single Does for Fast Relief.

Frequently Asked Questions

What is Trelli?

Trelli formulates clinically validated, naturally derived bioactives designed to relieve symptoms fast, without the downsides of traditional OTC solutions. Our products work at onset, not with daily maintenance, offering the trust of the OTC aisle with the peace of mind of nature.

Why was Trelli created?

Trelli was created to bridge the gap between natural and clinically effective relief. Too often, people are forced to choose between harsh, synthetic OTC drugs that work and natural options that don’t. We believed there had to be a better way.

Our team of scientists, doctors, and formulation experts set out to create products that deliver the same fast, reliable symptom relief as traditional medicine using naturally derived bioactives with proven clinical efficacy. The result is a new standard of care, one that’s effective, safer, and guilt-free to take at the first sign of discomfort.

What does Trelli mean?

Trelli comes from the idea of a trellis, a structure that supports natural growth and strength. Just as a trellis helps a plant reach its full potential, Trelli is designed to help your body restore balance and resilience when symptoms arise.

It reflects our belief that nature, guided by science, can provide powerful, reliable relief without compromise.

What are clinical bioactives?

Clinical bioactives are naturally derived compounds sourced from plants, botanicals, and other natural origins that contain specific active components responsible for measurable physiological effects. Within each plant profile, there are bioactive molecules that influence pathways in the body related to pain, inflammation, digestion, or respiratory function.

At Trelli, we identify these bioactive components, then extract, standardize, or bio-optimize them to enhance their absorption and stability. The result is a clinically validated ingredient with a defined mechanism of action that drives targeted, fast-acting symptom relief. Each Trelli formula combines these bioactives in precise ratios to deliver the same level of relief you’d expect from an OTC solution, but with a cleaner, lower-risk profile.

Why do we use naturally derived ingredients?

Nature has a remarkable chemistry of its own. We use bioactives sourced from plants, botanicals, and other natural origins because they deliver real relief without relying on harsh synthetics. When optimized through science, these natural compounds can work as effectively as conventional solutions but with a lower-risk profile.

What is a bio-optimized ingredient?

A bio-optimized ingredient is a natural compound enhanced for absorption, stability, and potency. It ensures each ingredient performs at its clinical potential in the body so you get meaningful relief, fast.

Why are you labeled as a supplement?

While Trelli products function more like medicine, effective in a single dose and designed for symptom relief, they are regulated under the dietary supplement category due to their naturally derived ingredient profile. This allows us to bring innovative, research-backed solutions to market while maintaining the highest standards for quality and safety.

How does Trelli compare to other natural products on the market?

Most natural products are made for long-term wellness, not fast relief. Trelli is different. Our formulations are built for immediate, clinically proven symptom relief, the kind you’d expect from an OTC, without the guilt or side effects. We call this new category Clinical Bioactives.

Are Trelli products safe to take consistently, if needed?

Yes. All Trelli products are made with clinically studied, well-tolerated ingredients and are safe for use as needed. Because they are non-habit-forming and have a lower risk of side effects, you can feel confident taking them whenever discomfort arises.

Where does Trelli manufacture its products?

All Trelli products are manufactured in the United States in cGMP-certified, FDA-registered facilities that meet the highest standards for safety, purity, and quality control.

How fast should I feel the effects of Trelli solutions?

Trelli products are designed for fast-acting relief. Most people begin to feel noticeable effects within 30 to 60 minutes, depending on the product and individual response.

Can I take Trelli products with other supplements or OTC medications?

In general, Trelli products are safe to use alongside most supplements and medications. However, because everyone’s health profile is unique, we recommend speaking with your healthcare provider before combining any products.

Can I take Trelli products if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, please consult your healthcare professional before use. While our ingredients are naturally derived and well-tolerated, your provider can best guide what is appropriate for your individual needs.