Palmitoylethanolamide (PEA) is a fatty acid amide naturally made in the body and found in foods like egg yolks and peanuts.

It helps reduce inflammation and pain by activating PPAR-α receptors and calming nerve and immune cells, making it a safe, natural option for relieving chronic and neuropathic pain without the side effects of traditional painkillers.

Caraway oil relieves digestive discomfort, primarily by relaxing smooth muscles in the stomach and intestines, which helps reduce cramping, bloating, and gas.

Caraway oil also exhibits antimicrobial and anti-inflammatory properties that may soothe inflamed digestive tissues and support gut health. It also has the ability to alleviate indigestion and improve symptoms related to functional dyspepsia, particularly when combined with peppermint oil.

Ivy leaf supports respiratory health by acting as an expectorant that loosens and thins mucus, making it easier to clear from the airways.

It has bronchodilator and anti-inflammatory properties that help relax bronchial muscles and reduce airway irritation, easing coughs and improving airflow. Ivy’s natural compounds also have antimicrobial effects, which may aid the body in fighting infections. These combined actions make ivy leaf a versatile natural remedy for improving breathing and relieving cough-related discomfort.

Honey and propolis both support the immune system through their antimicrobial and anti-inflammatory properties.

Honey soothes the throat and acts as a natural antibacterial agent, helping to fight infections and reduce irritation. Propolis, a resin produced by bees, is rich in flavonoids and compounds that stimulate immune cells, enhance antibody production, and regulate inflammation. Propolis has demonstrated immunomodulatory effects by activating macrophages and T-lymphocytes, boosting both innate and adaptive immunity.

Thyme supports respiratory health by acting as a natural expectorant, helping to loosen and clear mucus from the airways.

Its compounds, especially thymol, provide anti-inflammatory and antimicrobial effects that reduce airway irritation and fight infections. Additionally, thyme’s spasmolytic properties help calm coughing and relax respiratory muscles, aiding easier breathing and comfort during respiratory distress.

Ginger helps relieve pain by blocking inflammation and calming pain pathways in the body.

Its key compounds, gingerols and shogaols, inhibit COX and LOX enzymes that produce inflammatory prostaglandins, while also acting on TRPV1 receptors to reduce pain signaling, making it effective for arthritis, muscle pain, and menstrual cramps.

Alpha-galactosidase is an enzyme that aids digestion by breaking down complex sugars found in various carbohydrates. These sugars are otherwise fermented by gut bacteria, producing gas and discomfort.

By breaking down these carbohydrates earlier in digestion, alpha-galactosidase reduces gas production, bloating, and digestive discomfort. It supports better nutrient absorption and helps maintain a balanced digestive environment.

Caffeine helps relieve pain by blocking adenosine receptors in the brain and nervous system, which reduces pain signaling and inflammation.

It also constricts blood vessels, easing headache and migraine pain, and enhances the effects of common painkillers like acetaminophen and ibuprofen by boosting their analgesic potency.

Fennel oil is known for strong digestive benefits, including reducing bloating, gas, and intestinal spasms.

Its active compound anethole relaxes smooth muscles in the gastrointestinal tract, easing cramps and promoting better digestion. Fennel oil also has anti-inflammatory and antimicrobial properties that help soothe intestinal irritation and support gut health.

Postbiotic used in Colomend offers digestive and immune health benefits and works by adhering to the gut lining, promoting a healthy bacterial balance, strengthening the gut barrier, and supporting the integrity of tight junctions.

This helps improve digestion, reduce gastrointestinal discomfort, and enhance immune responses. Backed by over a century of research and more than 40 clinical studies.

Elderberry is rich in anthocyanins, powerful antioxidants that support immune health by reducing inflammation and protecting cells from oxidative stress.

These compounds also promote the growth of beneficial gut bacteria, which can enhance immune function through the gut-lung axis. Elderberry extracts have demonstrated antiviral activity and may help shorten the duration of respiratory illnesses by boosting the body's immune response naturally.

Alpinia galanga has been shown to significantly reduce fatigue and enhance mental alertness, focus, and energy without the side effects of caffeine.

Its bioactive compounds improve reaction time, accuracy, and attention, with effects lasting up to 5-7 hours after consumption. Alpinia also supports antioxidant defenses and neurotransmitter balance, helping reduce mental fatigue and daytime sleepiness.

Andrographis is used to reduce the duration and severity of symptoms associated with upper respiratory infections.

It works as an immune system stimulant by increasing antibody activity and enhancing macrophage function, which helps the body fight infections more effectively. Andrographis has demonstrated anti-inflammatory and antiviral properties, which contribute to symptom relief, including reducing sore throat, cough, and fever.

Reishi mushrooms support immune health by boosting the activity and number of white blood cells, which are crucial for fighting infections and maintaining immune defense.

Compounds like beta-glucans in reishi stimulate immune cells such as macrophages and natural killer cells, enhancing the body's ability to detect and eliminate pathogens. Additionally, reishi exhibits anti-inflammatory effects that help regulate immune responses and may reduce chronic inflammation.

Peppermint oil relaxes smooth muscles throughout the gastrointestinal tract by blocking calcium channels, which helps reduce muscle spasms and cramping.

It also has anti-inflammatory and antimicrobial effects, contributing to improved digestion and reduced irritation. Peppermint oil can modulate nerve sensitivity in the gut, decreasing discomfort and pain sensations.